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KMID : 0857020020170010152
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Kosin Medical Journal
2002 Volume.17 No. 1 p.152 ~ p.156
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A case of POEMS syndrome
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Seo Soo-Hong
Kim Yang-Soo
Eo Wan-Kyu
Chang Seong-Hoon
Shin Chae-Hee
Choi Byoung-Joo
No Chee-Whan
Kim Hyo-Kyoung
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Abstract
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The POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, skin change) is a rare multisystemic disorder of unknown pathogenesis. Although the etiology is still unclear, proinflammatory cytokines such as tumor necrosis factor-α, IL-6. and paraprotein specificity for neuroendocrine tissue have been suggested to play a causative role. We report a case of POEMS syndrome presented as progressive sensorimotor neuropathy, hapatosplenomegaly, diabetes mellitus, solitary bone plasmacytoma, hypertrichosis and hyperpigmentation. The patient was treated with local irradiation and prednisolone and showed obvious neurological and systemic improvement.
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KEYWORD
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POEMS syndrome, Plasmacytoma, Neuropathy
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